Abstract R-loops are three-stranded nucleic acid structures that can cause replication stress by blocking replication fork progression. However, the detailed mechanism underlying the collision of DNA replication forks and R-loops remains el... Read More
Abstract Inflammasomes are important sentinels of innate immune defense; they sense pathogens and induce the cell death of infected cells, playing key roles in inflammation, development, and cancer. Several inflammasome sensors detect and r... Read More
In a groundbreaking collaboration, UNIST and the University of Ulsan College of Medicine joined forces to host the inaugural ‘UUCM & UNIST Digital Healthcare Hackathon.‘ The event took place in the Market Hall and Event Hall... Read More
Abstract Dopamine neurons are essential for voluntary movement, reward learning, and motivation, and their dysfunction is closely linked to various psychological and neurodegenerative diseases. Hence, understanding the detailed signaling me... Read More
Abstract Dopamine synapses play a crucial role in volitional movement and reward-related behaviors, while dysfunction of dopamine synapses causes various psychiatric and neurological disorders. Despite this significance, the true biological... Read More
Yu Jin Lee, a research professor in the Department of Life Sciences at UNIST, has been honored with the prestigious Amgen-KAST Biotechnology Award. This esteemed award recognizes exceptional research accomplishments in the fields of life sc... Read More
Abstract Autophagy functions in cellular quality control and metabolic regulation. Dysregulation of autophagy is one of the major pathogenic factors contributing to the progression of nonalcoholic fatty liver disease (NAFLD). Autophagy is i... Read More
With obesity rates projected to continue rising globally, there is an urgent need to understand the intricate mechanisms that contribute to metabolic diseases such as diabetes. Addressing this critical issue head-on, Professor Jiyoung Park... Read More
Abstract Replication protein A (RPA), a eukaryotic single-stranded DNA (ssDNA) binding protein, dynamically interacts with ssDNA in different binding modes and plays essential roles in DNA metabolism such as replication, repair, and recombi... Read More
Abstract Entosis is a non-apoptotic cell death process that forms characteristic cell-in-cell structures in cancers, killing invading cells. Intracellular Ca2+ dynamics are essential for cellular processes, including actomyosin contractilit... Read More
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