Abstract Activation of hypoxia-inducible factor 1α (HIF1α) contributes to blood-retinal barrier (BRB) breakdown and pathological neovascularization responsible for vision loss in ischemic retinal diseases. During disease progression, mitoch... Read More
Abstract Adipose tissue within the tumor microenvironment (TME) plays a critical role in supporting breast cancer progression. In this study, we identified FAM3 metabolism-regulating signaling molecule C (FAM3C) produced by cancer-associate... Read More
Professor Jiyoung Park from the Department of Biological Sciences at UNIST, has been honored with the prestigious ‘KSMCB Award for Women in Life Science‘ at the 2023 International Conference of the Korean Society for Molecular a... Read More
Abstract Natural killer (NK) cells are innate lymphoid cells that play a pivotal role in anticancer immunity, and significant efforts have been made to develop effective NK cell-engagers that recruit and activate NK cells to treat cancers.... Read More
The Circle Foundation (formerly known as the Ahn Cheol-Soo Foundation) is actively supporting the development of technology to treat high-risk novel viral infectious diseases, including COVID-19. As part of their efforts, Professor Sangjun... Read More
Abstract R-loops are three-stranded nucleic acid structures that can cause replication stress by blocking replication fork progression. However, the detailed mechanism underlying the collision of DNA replication forks and R-loops remains el... Read More
Abstract Inflammasomes are important sentinels of innate immune defense; they sense pathogens and induce the cell death of infected cells, playing key roles in inflammation, development, and cancer. Several inflammasome sensors detect and r... Read More
Abstract Dopamine neurons are essential for voluntary movement, reward learning, and motivation, and their dysfunction is closely linked to various psychological and neurodegenerative diseases. Hence, understanding the detailed signaling me... Read More
Abstract Dopamine synapses play a crucial role in volitional movement and reward-related behaviors, while dysfunction of dopamine synapses causes various psychiatric and neurological disorders. Despite this significance, the true biological... Read More
The ‘Leukemia High-Precision BioResearch Group (Tentative Name),’ a collaboration established in February 2022 between UNIST and Uijeongbu Eulji Medical Center, organized a seminar on the latest advancements in blood cancer diag... Read More
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