Abstract Faithful chromosome segregation requires the removal of all DNA bridges physically linking chromatids before the completion of cell division. While several redundant safeguard mechanisms to process these DNA bridges exist from S-ph... Read More
Abstract Fast and accurate identification of pathogenic microbes in patient samples is crucial for the timely treatment of acute infectious diseases such as sepsis. The fluorescence in situ hybridization (FISH) technique allows the rapid de... Read More
Abstract Proton tunneling through a hydrogen bond is a significant quantum phenomenon in proton-mediated processes. Hydrogen bonds strengthen each other through cooperative interactions, enhancing proton tunneling. Controlling cooperativity... Read More
Abstract Genome-wide identification of binding profiles for DNA-binding proteins from the limited number of intracellular pathogens in infection studies is crucial for understanding virulence and cellular processes but remains challenging,... Read More
Numerous anti-cancer drugs function by targeting the DNA within cancerous cells, halting their proliferation. Yet, cancer cells occasionally develop mechanisms to repair the damage inflicted by these drugs, diminishing their effectiveness.... Read More
Four exceptional UNIST graduate students have been honored with the prestigious 2024 Asan Foundation Medical Bioscience Scholarship, a distinguished accolade bestowed upon the nation’s most outstanding graduate students in medical bio... Read More
Abstract R-loops are three-stranded nucleic acid structures that can cause replication stress by blocking replication fork progression. However, the detailed mechanism underlying the collision of DNA replication forks and R-loops remains el... Read More
Abstract Homologous recombination (HR) requires bidirectional end resection initiated by a nick formed close to a DNA double-strand break (DSB), dysregulation favoring error-prone DNA end-joining pathways. Here we investigate the role of th... Read More
An international symposium on precision oncology, with a focus on the possibility of conquering cancer through genome-based precision medical care, will be hosted by UNIST. Jointly organized by UNIST, Asan Medical Center, and the Institute... Read More
DNA is well known as the blueprint of life, necessary for an organism to facilitate living processes. DNA can be damaged by various factors such as radical metabolites, radiation, and some toxic chemicals. As DNA is a molecule consisting of... Read More
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