EndotrophinUNIST News Center | UNIST News Center

Targeting COL6A3-C5 with Nigericin to Reduce Endotrophin and Enhance Metabolic Health in Obesity

Their findings have been published on in Experimental & Molecular Medicine on March 5, 2026.

Abstract Endotrophin, a cleavage product of collagen VIα3 (COL6A3), contributes to fibroinflammation in adipose tissue and exacerbates systemic insulin resistance in obesity. Previously, we demonstrated that various hypoxia-induced matrix m... Read More

New Study Identifies How Obesity-Related Liver Cancer Becomes More Aggressive and Resistant to Treatment

The findings of this research have been published online in Cancer Research—a leading journal of the American Association for Cancer Research (AACR)—on February 11, 2026.

Abstract Endotrophin (ETP) is a cleavage fragment of collagen VI α3 (COL6A3) that functions as a potent fibrotic and pro-tumorigenic factor. ETP is a diagnostic and prognostic biomarker in hepatocellular carcinoma (HCC), continuously increa... Read More

Mar 18, 2026 By JooHyeon Heo Research

Unraveling the Link between Obesity, Diabetes, and Endotrophin

The study findings have been published ahead of their official publication in the online version of Metabolism on June 10, 2023.

With obesity rates projected to continue rising globally, there is an urgent need to understand the intricate mechanisms that contribute to metabolic diseases such as diabetes. Addressing this critical issue head-on, Professor Jiyoung Park... Read More

Jul 14, 2023 By JooHyeon Heo Research

New Therapeutic Avenue in the Fight Against Chronic Liver Disease

Their findings have been published in Journal of Pathology, one of the leading scientific journals in the field of pathology.

Chronic liver disease is known as the silent killer, as it shows no obvious symptoms until the disease has progressed to an advanced stage. Therefore, making a proper diagnosis in the early stage of disease progression can be a clinical cha... Read More

Oct 29, 2018 By JooHyeon Heo Research

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