Abstract Faithful chromosome segregation requires the removal of all DNA bridges physically linking chromatids before the completion of cell division. While several redundant safeguard mechanisms to process these DNA bridges exist from S-ph... Read More
Abstract Genome-wide identification of binding profiles for DNA-binding proteins from the limited number of intracellular pathogens in infection studies is crucial for understanding virulence and cellular processes but remains challenging,... Read More
Abstract R-loops are three-stranded nucleic acid structures that can cause replication stress by blocking replication fork progression. However, the detailed mechanism underlying the collision of DNA replication forks and R-loops remains el... Read More
Abstract Homologous recombination (HR) requires bidirectional end resection initiated by a nick formed close to a DNA double-strand break (DSB), dysregulation favoring error-prone DNA end-joining pathways. Here we investigate the role of th... Read More
Abstract While global transcription factors (TFs) have been studied extensively in Escherichia coli model strains, conservation and diversity in TF regulation between strains is still unknown. Here we use a combination of ChIP-exo–to define... Read More
Abstract TRAIP is a key factor involved in the DNA damage response (DDR), homologous recombination (HR) and DNA interstrand crosslink (ICL) repair. However, the exact functions of TRAIP in these processes in mammalian cells are not fully un... Read More
“The amount of data we generate everyday is truly mind-boggling. In other words, depending on which analytical strategy you establish, you can make important discoveries and thus gain better understanding of cell conditions or disease... Read More
A new study, affiliated with UNIST has recently presented a novel statistical algorithm, capable of identifying potential disease genes in a more accurate and cost-effective way. This algorithm has also been considered as a new promising ap... Read More
![[UNIST Webinar] AI enabled Computational Imaging for Biomedical Applications](https://news.unist.ac.kr/wp-content/uploads/2022/10/Session-13.18-296x166.jpg)