Abstract Reciprocal signaling between metanephric mesenchyme (MM) and ureteric bud (UB) is essential for human kidney development. However, human pluripotent stem cell-derived kidney organoids do not incorporate UB differentiation, limiting... Read More
Abstract Triggering cancer cell death by inducing DNA damage is the primary aim of radiotherapy; however, normal cells are also damaged. In this study, we showed that delivery of only four synthetic guide RNAs with Cas9 endonuclease efficie... Read More
Abstract Heterogeneity and the absence of a tumor microenvironment (TME) in traditional patient-derived organoid (PDO) cultures limit their effectiveness for clinical use. Here, Embedded Bioprinting-enabled Arrayed PDOs (Eba-PDOs) featuring... Read More
Abstract The application of organoids has been limited by the lack of methods for producing uniformly mature organoids at scale. This study introduces an organoid culture platform, called UniMat, which addresses the challenges of uniformity... Read More
Abstract Organ-on-a-chip, which recapitulates the dynamics of in vivo vasculature, has emerged as a promising platform for studying organ-specific vascular beds. However, its practical advantages in identifying vascular-targeted drug delive... Read More
Abstract Several stomach diseases are attributed to the dysregulation of physiological function of gastric mucosal barrier by pathogens. Gastric organoids are a promising tool to develop treatment strategies for gastric infections. However,... Read More
Abstract Blood–brain barrier (BBB) remains one of the critical challenges in developing neurological therapeutics. Short single-stranded DNA/RNA nucleotides forming a three-dimensional structure, called aptamers, have received increasing at... Read More
Abstract A growing body of evidence has indicated that white adipose tissue (AT) remodeling is a major trigger for obesity-associated metabolic complications. However, the scarcity of translational models is an obstacle to the development o... Read More
A summer exchange program, operated by UNIST and and Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS), ended with great success. The program, which consisted of four weeks of intensive hands-on education, created ne... Read More
UNIST and Ulsan will initiate a research collaboration to develop human organs-on-chips in hoping to reduce the time and cost for new drug discovery. The UNIST-WRIRM-UniBasel Organ Mimetic Research Center has announced that it has been sele... Read More
![[UNIST Webinar] AI enabled Computational Imaging for Biomedical Applications](https://news.unist.ac.kr/wp-content/uploads/2022/10/Session-13.18-296x166.jpg)