Human Coronavirus 3CL Proteases Cleave Septins and Disrupt HH Signaling, Causing Ciliary Dysfunction
The study findings have been published ahead of their official publication in the online version of J. Med. Virol. on February 24, 2023.
Abstract Coronaviruses target ciliate cells causing the loss of cilia, acute rhinorrheas, and other ciliopathies. The loss of ciliary function may help the virus infect, replicate, and spread. However, the molecular mechanisms by which coro... Read More
Structures of Vac8-containing Protein Complexes Reveal the Underlying Mechanism by which Vac8 Regulates Multiple Cellular Processes
The findings of this research have been published in the April 2023 issue of PNAS.
Abstract Vac8, a yeast vacuolar protein with armadillo repeats, mediates various cellular processes by changing its binding partners; however, the mechanism by which Vac8 differentially regulates these processes remains poorly understood. V... Read More