DNA ReplicationUNIST News Center

World’s First Real-Time Visualization of DNA Replication Unveils Unprecedented Scientific Insights

Their findings have been published in the online version of Nucleic Acids Research on November 22, 2023.

Abstract R-loops are three-stranded nucleic acid structures that can cause replication stress by blocking replication fork progression. However, the detailed mechanism underlying the collision of DNA replication forks and R-loops remains el... Read More

Researchers Uncover NSMF Protein’s Role in Relieving DNA Replication Stress

The study findings have been published ahead of their official publication in the online version of Nucleic Acids Research on June 28, 2023.

Abstract Replication protein A (RPA), a eukaryotic single-stranded DNA (ssDNA) binding protein, dynamically interacts with ssDNA in different binding modes and plays essential roles in DNA metabolism such as replication, repair, and recombi... Read More

Jul 13, 2023 By JooHyeon Heo Research

Researchers Solve Puzzle of How Cells Select DNA Damage Repair Pathways

Distinguished Professor Kyungjae Myung's research team discovers a new function of mismatch repair protein MSH2-MSH3 in DNA double-strand break repair.

Their findings have been published in the May 2023 issue of Nucleic Acids Research.

Researchers Solve Puzzle of How Cells Select DNA Damage Repair Pathways

DNA is well known as the blueprint of life, necessary for an organism to facilitate living processes. DNA can be damaged by various factors such as radical metabolites, radiation, and some toxic chemicals. As DNA is a molecule consisting of... Read More

May 16, 2023 By JooHyeon Heo Research

An Effective Sweeper Closes DNA Replication Cycling

Their findings have been published in Nature Communications June 3, 2019.

DNA replication is essential for living organisms to faithfully deliver genetic information from parental cells to daughter cells. Many proteins are assembled on the parental DNA to work as replication machineries. Among them, the prolifera... Read More

Jul 03, 2019 By JooHyeon Heo Research

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