Abstract Triggering cancer cell death by inducing DNA damage is the primary aim of radiotherapy; however, normal cells are also damaged. In this study, we showed that delivery of only four synthetic guide RNAs with Cas9 endonuclease efficie... Read More
Abstract Faithful chromosome segregation requires the removal of all DNA bridges physically linking chromatids before the completion of cell division. While several redundant safeguard mechanisms to process these DNA bridges exist from S-ph... Read More
Numerous anti-cancer drugs function by targeting the DNA within cancerous cells, halting their proliferation. Yet, cancer cells occasionally develop mechanisms to repair the damage inflicted by these drugs, diminishing their effectiveness.... Read More
Abstract Homologous recombination (HR) requires bidirectional end resection initiated by a nick formed close to a DNA double-strand break (DSB), dysregulation favoring error-prone DNA end-joining pathways. Here we investigate the role of th... Read More
DNA is well known as the blueprint of life, necessary for an organism to facilitate living processes. DNA can be damaged by various factors such as radical metabolites, radiation, and some toxic chemicals. As DNA is a molecule consisting of... Read More
Diagnosis of cancers may be one of the worst news to patients and their families. Conventional treatment options such as radiation and chemotherapies often kill not only cancer cells but also normal cells, which results in painful side effe... Read More
Harvard Medical School Professor William G. Kaelin Jr., one of the 2019 Nobel Laureates in Physiology or Medicine, is visiting UNIST on Tuesday, November 5, 2019. This visit is held on an invitation from Director Kyungjae Myung of IBS Cente... Read More
DNA replication is essential for living organisms to faithfully deliver genetic information from parental cells to daughter cells. Many proteins are assembled on the parental DNA to work as replication machineries. Among them, the prolifera... Read More
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