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    • [UNISTar Success Stories] UNIST Alumni Leads Development of Solar Hydrogen Panels at NREL 1 day ago
    • The Role of Motility in Bacterial Partitioning and Active Matter Dynamics in Aqueous Two-Phase Systems 1 day ago
    • Mathematics Comes Alive–Math Festa 2025 to Take Place 2 days ago
    View all
    • Mathematics Comes Alive–Math Festa 2025 to Take Place 2 days ago
    • UNIST and PNU Sign MOU to Foster Deep-Tech Startup Ecosystem in Korea’s Southeastern Region 2 days ago
    • CheongMyeong Advanced Materials Donates KRW 50 Million to Support Innovation and Startup Growth at UNIST 4 days ago
    View all
    • [UNISTar Success Stories] UNIST Alumni Leads Development of Solar Hydrogen Panels at NREL 1 day ago
    • UNIST Student Becomes First Korean to Win Global Quantitative Investment Competition 2 weeks ago
    • UNIST Secures Top Position at Korea’s Premier Autonomous Driving Competition 3 weeks ago
    View all
    • UNIST and PKNU Sign MOU to Promote Educational Donations and Develop Joint STEM Programs in Gyeongsang Region 2 months ago
    • UNIST Connects with Community Through Spring Concert for Children with Disabilities 6 months ago
    • Flower Beds at UNIST Given A New Lease of Life! 4 years ago
    View all
    • The Role of Motility in Bacterial Partitioning and Active Matter Dynamics in Aqueous Two-Phase Systems 1 day ago
    • New Study Unveils Opal-Inspired Structural Color Polymer Particles with Nano-Hole Architecture 3 days ago
    • Innovative AI Technology Enables Rapid, Cost-Effective Inspection of Nuclear Power Plant Equipment Using Single Seismic Sensor 4 days ago
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Home IBS Center for Genomic Integrity

New Gene Editing Technology Enables Selective Destruction of Cancer Cell DNA Using Fewer Targets

This study was published in Cancer Research, the official journal of the American Association for Cancer Research (AACR) on August 1, 2025.

New Gene Editing Technology Enables Selective Destruction of Cancer Cell DNA Using Fewer Targets

Abstract Triggering cancer cell death by inducing DNA damage is the primary aim of radiotherapy; however, normal cells are also damaged. In this study, we showed that delivery of only four synthetic guide RNAs with Cas9 endonuclease efficie... Read More

Sep 17, 2025 By JooHyeon Heo Research
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New Insights into Safe Cell Division: Key Protein as the Last Line of Defense Against DNA Bridges

Their findings have been published in Nucleic Acids Research on April 11, 2025.

New Insights into Safe Cell Division: Key Protein as the Last Line of Defense Against DNA Bridges

Abstract Faithful chromosome segregation requires the removal of all DNA bridges physically linking chromatids before the completion of cell division. While several redundant safeguard mechanisms to process these DNA bridges exist from S-ph... Read More

May 20, 2025 By JooHyeon Heo Research
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New Study Unveils How A Natural Compound from Sea Squirts Combats Cancer

Scientists have deciphered how trabectedin outsmarts cancer cells’ DNA repair mechanism, paving the way for tailored treatments.

Their findings have been published in the February 2024 issue of Nature Communications.

New Study Unveils How A Natural Compound from Sea Squirts Combats Cancer

Numerous anti-cancer drugs function by targeting the DNA within cancerous cells, halting their proliferation. Yet, cancer cells occasionally develop mechanisms to repair the damage inflicted by these drugs, diminishing their effectiveness.... Read More

Mar 13, 2024 By JooHyeon Heo Research
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Breakthrough Research Uncovers Key Mechanism in DNA Repair Process

The work by Distinguished Professor Kyungjae Myung has been published in the online version of Nucleic Acids Res. on September 22, 2023.

Breakthrough Research Uncovers Key Mechanism in DNA Repair Process

Abstract Homologous recombination (HR) requires bidirectional end resection initiated by a nick formed close to a DNA double-strand break (DSB), dysregulation favoring error-prone DNA end-joining pathways. Here we investigate the role of th... Read More

Oct 24, 2023 By JooHyeon Heo Research
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Researchers Solve Puzzle of How Cells Select DNA Damage Repair Pathways

Distinguished Professor Kyungjae Myung's research team discovers a new function of mismatch repair protein MSH2-MSH3 in DNA double-strand break repair.

Their findings have been published in the May 2023 issue of Nucleic Acids Research.

Researchers Solve Puzzle of How Cells Select DNA Damage Repair Pathways

DNA is well known as the blueprint of life, necessary for an organism to facilitate living processes. DNA can be damaged by various factors such as radical metabolites, radiation, and some toxic chemicals. As DNA is a molecule consisting of... Read More

May 16, 2023 By JooHyeon Heo Research
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Scientists develop New Platform Technology for Personalized Cancer Therapy

The work by Distinguished Professor Kyungjae Myung's team has been published in PNAS.

A new therapy called CINDELA (Cancer-Specific InDel Attacker) employs CRISPR-Cas9 to kill cancer cells without affecting normal tissues.

Scientists develop New Platform Technology for Personalized Cancer Therapy

Diagnosis of cancers may be one of the worst news to patients and their families. Conventional treatment options such as radiation and chemotherapies often kill not only cancer cells but also normal cells, which results in painful side effe... Read More

Feb 28, 2022 By IBS Communications Team Research
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2019 Nobel Laureate in Medicine Visits UNIST

Dr. William G. Kaelin Jr. will deliver a special lecture for UNIST students on November 5, 2019.

2019 Nobel Laureate in Medicine Visits UNIST

Harvard Medical School Professor William G. Kaelin Jr., one of the 2019 Nobel Laureates in Physiology or Medicine, is visiting UNIST on Tuesday, November 5, 2019. This visit is held on an invitation from Director Kyungjae Myung of IBS Cente... Read More

Oct 31, 2019 By JooHyeon Heo News
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An Effective Sweeper Closes DNA Replication Cycling

Their findings have been published in Nature Communications June 3, 2019.

An Effective Sweeper Closes DNA Replication Cycling

DNA replication is essential for living organisms to faithfully deliver genetic information from parental cells to daughter cells. Many proteins are assembled on the parental DNA to work as replication machineries. Among them, the prolifera... Read More

Jul 03, 2019 By JooHyeon Heo Research
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Global News

  • New Smartphone App Offers Convenient Way to Diagnose Sleep Apnea
  • [Korea Bizwire] June, 4, 2024

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  • [Korea Biomedical Rev.] June, 4, 2024

  • Study reveals promising technology for sepsis treatment using functional magnetic nanoclusters
  • [Phys.org] May,27, 2024

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